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Biomune™ OSF Plus |
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| Clinical studies such as Dr. Jesse Stoff’s study of the ingredients
included in Matol Biomune OSF Plus™ , document the changes experienced
by participants who have a specific goal relative to their well-being.
These studies appear, in contrast to academic studies, often referred to
as "double blind" that are applied to drugs with the intent of
establishing the nature of a substance and its effects on the subject. The questions "what if ?" and "how do we?" are found in studies where the "outcome" is not the main goal. In clinical studies "outcome" is everything. The study itself is a documentation of the "outcome". The only pre-qualifying condition for Dr. Stoff’s studies is the presence of illness. |
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| A Comparison of Quantum Research, Inc.’s Special Bovine Colostrum/Whey
Extract to Other Colostrum and Whey Products When Dr. Stoff was asked the difference between the Quantum Research extract of bovine colostrum/whey and other colostrum and whey products, his answer was, "That’s easy. One works and one doesn’t." If you ask how he made that evaluation, he reminds the questioner that he has, for nearly four years, conducted extensive clinical research on the Quantum extract formulations and other colostrum products. He knows from actual clinical experience that regular colostrum may have some value, but has a minimal effect upon any significant immune response. Dr. Olsztyn and Dr. Stoff believe that the Quantum colostrum/whey extracts are elite and in a class of their own. To be compared to other colostrum and whey products is inevitable, but much like comparing milk to gold such comparisons are meaningless. There is simply nothing tangible to compare. Reviewing literature of companies that market colostrum or whey products one would get the impression that their commodity is absolutely the most fantastic immune support substance that ever existed. In fact, they probably say that somewhere in self-aggrandizing literature. The Quantum Research formulations are not in competition with any colostrum or whey products as there is very little comparison, other than the Quantum extract has its origin in cows, as does most regular colostrum. There is nothing wrong with the commodity colostrum or whey. Both are a good source of protein and as Dr. Stoff said, "they are better than nothing". What are the distinct and important differences between the Quantum Research colostrum/whey extract formula and other formulas? Quantum Research’s formulation of a special extract of colostrum/whey and immune synergists that includes herbs, and other natural substances. Other colostrum or whey products are simply a commodity like milk or wheat. Quantum Research formulations have been clinically tested for their effectiveness by medical doctors before being released to the general public. These clinical studies are also made available to the public. Quantum Research products include a special extract of colostrum/whey that is produced by a patented pre-calving process of immunological stimulation from an exclusive herd of clean (antibiotic, hormone, pesticide free) and privately managed herd of cattle. A proprietary post-calving process of select collection, ultra-filtration and low heat drying produces a collection of very small molecules that contain transfer factor and other immunological factors. Less than 1% of the original colostrum/whey is retained and only specific molecules are harvested. The same material marketed by other companies as colostrum or whey is discarded and thrown away through this precise process. |
The Importance of Natural Killer Cells |
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| The clinical study by Dr. Stoff focused on the ability of the
ingredients in Biomune OSF Plus™ to increase NK cell function. Any
statement that natural killer (NK) cells play an "important
role" in human health is as casual as saying that the brain is
important for bodily function. If our brain is not present and active, we
cannot continue "living". If our immune system is not armed and
working well, we will also not continue "living" for very long.
NK cell activity is to the immune system what brain activity is to body. The immune system is comprised of millions of cells, numerous chemicals, glands and organs which all work together via a complex communication system. Immune science uses terms like "antibodies", "antigens", "B cells", "T cells", "macrophages", "cytokines", and in the past few years, "natural killer cells". Natural killer cells have become the focus of much research due to the expanding knowledge of their value in keeping us healthy. NK cell activity and NK cell count are not the same. NK cells may be present in sufficient numbers, but unless they are activated they are ineffective in doing their job. Decreased NK cell activity is linked to the development and progression of many diseases. According to the Center for Disease Control, low NK cell activity is present in all illness. NK cell function appears to be a biologic marker for disease and is an important indicator for declining or improving health. The following assertion can be made; if one is suffering from an illness, be it chronic, recurring or acute, the NK cell activity would be below normal. The restoration of NK cell activity to a high normal would be desirable, if not necessary, for recovery. With this in mind, a strategy to accomplish increasing NK cell activity should accompany both the maintenance of good health and the recovery from illness. |
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Low NK cell activity begins with stress of some type. When the body is
unable to adequately adapt to the environment, there is a resulting
compromise of body function. Stress comes through loss of sleep, overwork,
emotional encounters, lack of exercise, poor nutrition, exposure to
toxins, exposure to germs etc. Acute low NK cell activity resulting from temporary stress can be eliminated with the elimination of the stress factor. For example, if we are over-tired and under-nourished, we can simply rest and eat properly for a few days and recover. However, when we become continually immune compromised we start developing recurring problems which may lead to serious or chronic conditions. Specific intervention can be necessary to rebuild the immune system in the face of serious or chronic conditions if recovery is to occur. At a certain point, rest and general nutrition are just not enough. This is when most people turn to pharmaceutical products for recovery and symptomatic relief. Unfortunately, this has not been a viable approach, as drugs do not address the deficiencies that are necessary for real and lasting recovery. Drugs do not build up the immune system and often produce a weakening in the long run. The lack of results and the many side effects of drugs have caused millions to turn to alternative approaches for their health recovery. There are numerous nutritional substances that support the immune system when taken in sufficient quantities and combinations. Vitamin A, vitamin C and vitamin E, zinc, calcium, goldenseal and echinacea, are just a few of the vitamins minerals and herbs that support the immune system. Vitamin C and vitamin E will increase NK cell activity slightly, but not dramatically nor consistently. In fact, the search for a safe and effective strategy to enhance NK cell activity and accordingly, provide effective immune system support has been in progress for several years. Dr. Stanley R. Olsztyn, a medical doctor specializing in alternative medicine, has been developing such products since the 1970’s. He has been working with and developing special colostrum/whey extracts in combination with herbs, vitamins and other nutritionals. Dr. Olsztyn discovered that colostrum/whey extracts with synergistic nutritional components did, in fact, increase NK cell activity both dramatically and consistently. This explained why the thousands of patients to whom he had given his formulas responded so well and so quickly. In 1993, after 15 years of clinical research and development, he introduced his results to the general public. Concurrently, Dr. Jesse A. Stoff, a prominent viro-immunologist and researcher, was exploring ways to expand his protocol for immune system support. He conducted extensive laboratory evaluation on his patients in his Tucson clinic and was searching for a "transfer factor" substance that he reason |
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CLINICAL STUDY |
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| THE USE OF DIALYZABLE BOVINE COLOSTRUM EXTRACT IN CONJUNCTION WITH A HOLISTIC TREATMENT MODEL FOR NATURAL KILLER CELL STIMULATION IN CHRONIC ILLNESS --------------------------------------------------------------- The following study discusses, summarizes and demonstrates that properly bovine colostrum and whey extracts used in combination with the herb Astragalus will help produce significant increases in Natural killer (NK) cell activity. NK cells are very important in human health and disease. Defective or absent NK cell activity is associated with a spectrum of human diseases. Matol Biomune OSF Plus tm, which combines the herb Astragalus with such an extract from Quantum Research, Inc. is shown to be a critical dietary supplement. --------------------------------------------------------------- THE USE OF DIALYZABLE BOVINE COLOSTRUM EXTRACT IN CONJUNCTION WITH A HOLISTIC TREATMENT MODEL FOR NATURAL KILLER CELL STIMULATION IN CHRONIC ILLNESS By: Jesse A. Stoff, MD, MFHOM, FACLM Abstract: A longitudinal evaluation of the natural killer cell (NK activity) of peripheral blood lymphocytes was performed in 107 patients with documented and advanced chronic illness and followed for an average period of 13.2 months. At the time of primary evaluation and treatment, the absolute value of natural killer cell activity was significantly lower than the normal range. Hence, the association of chronic illness with the syndrome of low natural killer cell activity. During the follow-up period, a variety of nutritional agents were given to support natural killer cell function and then dialyzable bovine colostrum extract was added to the protocol. In the ensuing months, the curve of NK cell reactivation into normal ranges and above was monitored as immune system competence was restored. The use of natural immunomodulators including the use of dialyzable bovine colostrum extract can be concluded as a viable therapeuticum in NK cell reactivation in the face of chronic illness. |
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Clinical Study Summary and Discussion |
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| The participants: Charts of 107 patients who presented with chronic illness which were known to include low NK cell function were studied to determine their NK cell function response after being treated with a complimentary medical regimen of therapy. This regimen included the use of dialyzable bovine colostrum/whey extracts as well as other elements of the Holistic Medical Paradigm. The patients all self-selected this medical approach and most came with specific expectations, having read (1) Chronic Fatigue Syndrome: The Hidden Epidemic or, (2) The Definitive Guide to Cancer Therapy. An overview of the immune system: The marvelous array of deftly interacting cells that defend our body against invaders, arise from a few precursor cells that first appear at about 9 weeks after conception. From that point on, the cells of the immune system go through a continuously repeated cycle of growth and development and become fully competent at around 6 months of age after our birth. The parent cells of our immune system are referred to as stem cells. These are the cells upon which the immune system depends to both reproduce itself and gives rise to the many specialized lineage's that spring from it; the B cells, macrophages, natural killer (NK) cells, helper T cells, etc. The cells of the immune system are not isolated in a single body space or arranged in the form of a single organ. Instead, the majority of them exist as potentially mobile entities unattached to other cells. This characteristic is crucial to their function. Every minute of every day, war is waged within our body. The combatants are too small to see. Some, like the infamous HIV virus, are so small that 230 million would fit on the period at the end of this sentence. Yet, they employ tactics that can vanquish the much larger cells upon which our immune system is based. Usually, we never even notice the battles within us. We have evolved legions of defenders, specialized cells that silently destroy the unseen enemy. Sometimes these warriors mistake harmless invaders such as pollen for deadly foes and trigger an allergic response. Occasionally, some of our own cells begin the mutinous uncontrolled proliferation characteristic of cancer and manage to evade the surveillance of our body's defensive forces. For every successful penetration of our defenses, millions of attempts are repelled. We sleep securely at night trusting the invisible vigilantes of our immune system. The science and practice of immunology traces back to 1721 to Lady Mary Wortley Montagu. She introduced England to a Turkish process of inoculation with unmodified smallpox virus in an attempt to stem the ravages of the normal course of the disease. Her techniques were quite crude and as many as her patients died as survived but those that survived were immune to the disease forever more. Over the decades and centuries, scores of doctors and researchers honed the art of immunology into a more and more refined science. Many of the wonderful blood tests that we have today and information that we now know about immunology was unknown to us a scant 20 years ago. Information on the science of immunology doubles at the rate of approximately every 5 to 6 years. So, we must remember that the wonderful ways that we have today to support and direct the immune system to help protect us and fight off illnesses is a mere foreshadow of things |
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REFERENCES |
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| 1. "Purification of transfer factors", Rosso, S.J. et al, Mol.
Immunol. 1992, Feb; 29(2): 167-82 2. Transfer factor is effective across different mammalian species. "Isolation and purification of HSV-1 specific transfer factor produced by HSV-1 immunized goat leukocyte dialysate" by Dr. Qitly et al, Acta Virol 1992, May; 36(3): 231-8 3. Transfer factor is just as effective when taken orally as by injection. "Murine transfer factors: dose-response relationships and routes of administration" Kirk Patrick, C.H., et al, Cell Immunol, 1995, Sep; 164(2): 203-6 4. "Transfer factor presents relapse in herpes keratitis patients; a pilot study" Pizza, G. et al, Biotherapy 1994; 8(1): 63-8 5. "Adjuvant treatment using transfer factor for bronchogenic carcinoma: long- term follow-up", Whyte, R.I. et al, Arr Thoracic Surgery, 1992, Mar; 53(3): 391-6 6. "Immunotherapy with transfer factor of recurrent herpes simplex type I", Estranda-Parra, S. et al, Arch Med Res, 1995;26 7. "Effect of Brucella abortus transfer factor in preventing murine brucellosis", Stevens, M.G. et al, Immunol Med Microbiol, 1995, Jul; 11(4): 279-84 8. "Transfer factor in malignancy", Pizza, G. et al, Prog Drug Res 1994; 42: 401-21 9. "Specific transfer factor with activity against Epstein-Barr virus reduces late relapse in endemic Burkitt’s lymphoma", Neequaye, J. et al, Anticancer Research 1990 Sept-Oct; 10 (5A): 1183-7 10. "A controlled trial of bovine dialyzable lukocyte extract (transfer factor) for cryptosporidiosis in patients with AIDS" McMeeking, A. et al, J. Infect Dis, 1990 Jan; 161(1): 108-12 11. Clark D, Wyatt K: Colostrum, Life’s First Food. Salt Lake City: CNR Publications, 1996. 12. Lange S: Immune mechanisms of cardiac disease. New England Journal Of Medicine 330(7): 1129, April 21, 1994. 13. Kohl S, et al: Human colostral cytotoxicity: antibody-dependent cellular cytotoxicity against herpes simplex infected cells mediated by colostral cells. Journal of Clinical Laboratory Immunology 1:221-224. 14. Acosta-Altamirano G, et al: Anti-amoebic properties of human colostrum. Adv Exp Med Biol 216B: 1347-1352, 1987. 15. Boesman-Finkelstein M., et al: Passive oral immunization of children. The Lancet. 49:1336, 1989. 16. Haynes BF, Fauci AS: Introduction to clinical immunology. Part II, section 2. in: Harrison’s Principles of Internal Medicine, Eleventh Edition. Braunwald E (eds), et al. New York: McGraw Hill Book Co, Janusz M, et al: Immunoregulatory properties of synthetic peptides: fragments of a proline-rich polypeptide from bovine colostrum. Molecular Immunology 24(10): 1029-1031, 1987. 17. Kim K, et al: In vitro and in vivo neutralizing activity of human colostrum and milk against purified toxins A and B of Clostridium difficile. T Infect Dis 150:57-61, 1985. 18. Ogra P, et al: Colostrum derived immunity and maternal neonatal interaction. Annals NY Acad Sci 409:82-92, 1983. 19. Palmer EL, et al: Antiviral activity of colostrum and serum immuno- globulins A and G. J Med Virol 5:123-129, 1980. 20. Sabirl, AB: Anti-poliomyelitic substance in milk from human beings and certain cow |
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Study Group Profile |
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| Background: NK cell activity (Lytic Units) in a healthy population 150-225 NK cell activity (Lytic Units) in the U.S. population 20-50 Study Group size and gender: 107 participants: 59 females 48 males Average age: 53 years Youngest: 17 years Oldest : 83 years Presenting disease as a percentage of the Total Study Group: Cancer 50% Chronic Fatigue Syndrome 30% Others 20% Including Lupus, Allergies, Fibromyalgia, Blood Disorders, Chronic Infections, Recurrent Infections, Autoimmune Diseases, and Cervical Dysplasia/Metaplasia. All Study Group participants recorded significantly higher NK cell activity. Average initial NK cell activity 18 Lytic Units. Average final NK cell activity 246 Lytic Units. Average monthly increase in NK cell activity by participants 28.25 Lytic Units. Average percentage of improvement 1,267%. Treatment period: Total participant treatment time 1,422 months. Average participant treatment time 13.2 months. Number of capsules used by participants: 2-8 per day. 20. |
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GRAPHIC ILLUSTRATION OF CLINICAL STUDY |
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| * Average NK Cell activity in a Healthy Population is 150-225 * Average U.S. Population NK Cell activity is 20-50 * Study includes over 1400 Treatment months for 107 patients * Average monthly increase by patients was 28.25 Lytic Units * Participant profile: Average age 53 ( youngest: 17 - oldest: 84) * Diseases presented by study participants - Cancer - Chronic Fatigue Syndrome - Lupus - AIDS, HIV - Hepatitis C - Allergies - Colitis - Chronic Infection * Low NK Cell count is associated with a wide spectrum of human illnesses.
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Biomune OSF Plus™ |
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| The potential benefits available through colostrum and whey are being
discussed everywhere. Claims of benefit from the consumption of
"Pure, Clean Colostrum" or "Filtered Whey" are
everywhere. Indeed, the benefit of breast-feeding infants has covered
magazine racks for years. Bovine colostum is touted as the "new" source of health. Bovine colostrum is now a commodity. Buyers and sellers from all over the world are being brought together for the purpose of creating a new marketable commodity. New companies have emerged to sell this commodity in various forms of "after-market" marketing. Though bovine colostrum has some demonstrated benefit, by itself bovine colostrum is not a silver bullet. It is simply another commodity like wheat or milk. As with all commodities, all are not created equal and do not contain equal characteristics. Quantum Research, Inc. and Dr. Jesse Stoff have demonstrated that high quality, highly controlled extracts can be combined with other nutritional ingredients to create significant products that can bring changes in the performance of the immune system. Quantum Research, Inc. is able to create the amazing extracts used in the products for several reasons. They use a proprietary technology, protected by a totally unique and protected patented process. They utilize a privately managed dairy herd that originated over thirty years ago. They access nearly forty years of experience in bovine colostrum collection and study. Dr. Stoff and/or Dr. Olsztyn have used these extracts for over twenty years in medical practice. Biomune OSF Plus™ utilizes the herb astragalus in combination with a special extract of dairy colostrum and whey. Clinical studies indicate that this combination creates a synergistic effect on the immune system resulting in elevation of NK cell activity.* ------------------------------------------------------------- Astragalus The herb Astragalus, with the Latin name, Astragalus membranaceus, is derived form the root of this perennial herb which is Chinese in origin and considered a traditional Chinese herb. Astragalus is considered an immune stimulation herb. The "stem cells" in the bone marrow are increased and their development is stimulated into active immune cells that are then released into the body. Essentially, every phase of the immune system activity is stimulated by Astragalus. Active ingredients contained in astragalus include bioflavanoids, choline, and astragalan B, a polysaccharide. Astragalan B has been shown in animal studies to be effective at protecting the body against a number of toxins, controlling bacterial infections and stimulating the immune system. Astragalan B appears to work by allowing the body’s immune system to attack the outer membranes of viruses, destabilizing their defenses and allowing them to be overwhelmed by the immune response. Astragalus increases interferon production and enhances NK and T cell function, increasing resistance to viral conditions. Astragalus has also been shown to support the body in peripheral vascular disease and peripheral circulation. Astragalus aids adrenal gland function that often needs support in chronic and degenerative health states. |